Publications

2024

Protocol for quantifying SA-β-gal activity as a measure of senescence in islets of a mouse model of type 1 diabetes

Lee H, Thompson PJ, Engin F.
STAR Protocols. 2024 Feb 29;5(1):102923. PMID: 38427571

2023

Stress-induced β-cell early senescence confers protection against type 1 diabetes

Lee H, Sahin GS, Chen CW, Canas SM, Sonthalia S, Duckworth AT, Oktay HZ, Brawerman G, Thompson PJ, Hatzoglou M, Eizirik DL, Engin F.
Cell Metab. 2023 Nov 5:S1550-4131(23)00383-2. PMID: 37949065.

Ormdl3 regulation of specific ceramides is dispensable for mouse β-cell function and glucose homeostasis under obesogenic conditions

Hurley L, Lee H, Wade G, Simcox J, Engin F.
Front Endocrinol. 2022. Apr 14:14:1170461. PMID: 37124760.

2022

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Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

Chen CW*, Alzahrani MR, Guan BJ, Gao Z, Gao L, Haataja L, Schaffer AE, Lee H, Laframboise T, Arvan P, Matthews CE, Gerling IC, Kaestner KH, Topisirovic I, Larson O, Engin F*, Hatzoglou M*
Nat Commun. 2022 Aug 8;13(1):4621. PMID: 35941159.

*Corresponding author

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Analysis of half a billion datapoints across ten machine-learning algorithms identify key determinants of insulin gene transcription

Wong, W.K.M,  Thorat V, Joglekar MV, Dong CX, Lee H, Chew, YV, Bhave A,  Hawthorne WJ,  Engin F, Pant A,  Dalgaard LT, Bapat S, Hardikar AA.
Front Endocrinol. 2022 Mar 23;13:853863. PMID: 35399953.

2021

A hormone complex of FABP4 and nucleoside kinases regulates islet function

Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GS.
Nature. 2021 Dec 600(7890):720-726. PMID: 34880500.

Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's

Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND; Symposium planning committee, moderators, and speakers:, Rosenblum N, Cefalu W, Andersen DK, Arreaza-Rubín G, Dhara C, James SP, Makarchuk MJ, Pin CL, Sato S, Verchere B, Woo M, Powers A, Estall J, Hoesli C, Millman J, Linnemann A, Johnson J, Pin CL, Hawkins M, Woo M, Gloyn A, Cefalu W, Rosenblum N, Huising MO, Benninger RKP, Almaça J, Hull-Meichle RL, MacDonald P, Lynn F, Melero-Martin J, Yoshihara E, Stabler C, Sander M, Evans-Molina C, Engin F, Thompson P, Shalev A, Redondo MJ, Nadeau K, Bellin M, Udler MS, Dennis J, Dash S, Zhou W, Snyder M, Booth G, Butte A, Florez J.

Diabetes Care. 2022 Jan 1;45(1):3-22. PMID: 34782355.
Diabetes. 2021 Nov 13;db210777. PMID: 34957490.
Can J Diabetes. 2021 45(8):697-713. PMID: 34794897.

An accomplice more than a mere victim: the impact of β-cell ER stress on type 1 diabetes pathogenesis

Sahin GS, Lee H, Engin F.
Mol Metab. 2021 Oct 30;54:101365. PMID: 34728341.

2020

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Preparing Highly Viable Single-Cell Suspensions from Mouse Pancreatic Islets for Single-Cell RNA Sequencing

Lee H, Engin F.
STAR Protocols. 2020 Oct 20;1(3):100144. PMID: 33377038.

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Differential Expression of Ormdl Genes in the Islets of Mice and Humans with Obesity.

Lee H, Fenske RJ, Akcan T, Domask E, Davis DB, Kimple ME, Engin F.
iScience. 2020 Jul 24;23(7):101324. PMID: 32659722.

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Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes.

Lee H, Lee YS, Harenda Q, Pietrzak S, Oktay HZ, Schreiber S, Liao Y, Sonthalia S, Ciecko AE, Chen YG, Keles S, Sridharan R, Engin F.
Cell Metab. 2020 Apr 7;31(4):822-836.e5. PMID: 32220307.

2017

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Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.

Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS.
Cell Rep. 2017 Oct 10;21(2):393-402. PMID: 29020626.

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The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice.

Fenske RJ, Cadena MT, Harenda QE, Wienkes HN, Carbajal K, Schaid MD, Laundre E, Brill AL, Truchan NA, Brar H, Wisinski J, Cai J, Graham TE, Engin F, Kimple ME.
Endocrinology. 2017 Jun 1;158(6):1645-1658. PMID: 28419211.

2016

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ER stress and development of type 1 diabetes.

Engin F.
J Investig Med. 2016 Jan;64(1):2-6. PMID: 26230493.

2015

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Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms.

Brozzi F, Nardelli TR, Lopes M, Millard I, Barthson J, Igoillo-Esteve M, Grieco FA, Villate O, Oliveira JM, Casimir M, Bugliani M, Engin F, Hotamisligil GS, Marchetti P, Eizirik DL.
Diabetologia. 2015 Oct;58(10):2307-16. PMID: 26099855

2014

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Aberrant islet unfolded protein response in type 2 diabetes.

Engin F, Nguyen T, Yermalovich A, Hotamisligil GS.
Sci Rep. 2014 Feb 11;4:4054. PMID: 24514745.

2013

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Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes.

Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS.
Sci Transl Med. 2013 Nov 13;5(211):211ra156. PMID: 24225943.

2010

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Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases.

Engin F, Hotamisligil GS.
Diabetes Obes Metab. 2010 Oct;12 Suppl 2:108-15. PMID: 21029307

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E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta.

Yang T, Mendoza-Londono R, Lu H, Tao J, Li K, Keller B, Jiang MM, Shah R, Chen Y, Bertin TK, Engin F, Dabovic B, Rifkin DB, Hicks J, Jamrich M, Beaudet AL, Lee B.
J Clin Invest. 2010 Jul;120(7):2474-85. PMID: 20530870.

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NOTCHing the bone: insights into multi-functionality.

Engin F, Lee B.
Bone. 2010 Feb;46(2):274-80. PMID: 20530870.

2009

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Notch signaling contributes to the pathogenesis of human osteosarcomas.

Engin F, Bertin T, Ma O, Jiang MM, Wang L, Sutton RE, Donehower LA, Lee B.
Hum Mol Genet. 2009 Apr 15;18(8):1464-70. PMID: 19228774.

2008

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Dimorphic effects of Notch signaling in bone homeostasis.

Engin F, Yao Z, Yang T, Zhou G, Bertin T, Jiang MM, Chen Y, Wang L, Zheng H, Sutton RE, Boyce BF, Lee B.
Nat Med. 2008 Mar;14(3):299-305. PMID: 18297084.

2006

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Dominance of SOX9 function over RUNX2 during skeletogenesis.

Zhou G, Zheng Q, Engin F, Munivez E, Chen Y, Sebald E, Krakow D, Lee B.
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19004-9. PMID: 17142326.