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Differential expression of Ormdl genes in the islets of mice and humans with obesity

Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes
H. Lee
Y. LeeQ. Harenda , S. Pietrzak H. Oktay , S. Schreiber Y. Liao S. Sonthalia A. Ciecko Y. ChenS. KelesR. Sridharan Feyza Engin
Cell Metabolism 2020 Apr 7;31(4):822-836.e5. doi: 10.1016/j.cmet.2020.03.002. Epub 2020 Mar 26.

Uncoupling of Metabolic Health from Longevity through Genetic Aleration of Adipose Tissue Lipid-Binding Proteins.
Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS.
Cell Rep. 2017  Oct 10;21(2):393-402.

The Inhibitory G Protien α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice.
Fenske RJ, Cadena MT, Harenda QE, Wienkes HN, Carbajal K, Schaid MD, Laundre E, Brill AL, Truchan NA, Brar H, Wisnski H, Cai J, Graham TE, Engin F, Kimple ME.
Endocrinology. 2017 Jun 1;158(6):1645-1658.

ER Stress and Development of Type 1 Diabetes
Engin F.
J Investig Med. 2015.

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms
Brozzi F, Nardelli TR, Lopes M, Millard I, Barthson J, Igoillo-Esteve M, Grieco, FA, Villate O, Oliveira JM, Casimir, M, Bugliani M, Engin F, Hotamisligil GS, Marchetti PM, Eizirik DL.
Diabetologia. 2015.

Aberrant islet unfolded protein response in type 2 diabetes.
Engin F, Ngyuen T, Yermalovich A, Hotamisligil GS.
Sci Rep. 2014. 11;4:4054.

Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes.
Engin F, Yermalovich A, Fu W, Ngyuen T, Hummasti S, Decio L, Eizirik, Mathis, D, Hotamisligil, GS.
Sci. Transl. Med. 2013.

Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases.
Engin, F, Hotamisligil GS.
Diabetes Obes. Metab. 2010. 12 Suppl 2:108-15.

E-Selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-β
Yang T, Londono R.M, Lu H, Li K, Keller B, Jiang M.M, Chen Y, Bertin T, Engin F, Dabovic B, Rifkin D.B, Hicks J, Beaudet A.L, Lee B.
J. Clin. Invest. 2010. 1; 120(7): 2474-85.

NOTCHing the bone: insights into multi-functionality
Engin F, Lee B.
Bone. 2010; 46(2): 274-280.

Notch signaling contributes to the pathogenesis of human osteosarcomas
Engin F, Bertin T, Ma O, Jiang MM, Wang L, Sutton RE, Donehower LA, Lee B.
Hum. Mol. Genet. 2009; 18(8): 1464-1470.

Dimorphic effects of Notch signaling in bone homeostasis
Engin F, Yao Z, Yang T, Zhou G, Bertin T, Jiang M.M, Chen Y, Wang L, Zheng L, Sutton R.E, Boyce B.F, Lee B.
Nat. Med. 2008; 14(3): 299-305.

• Understanding of human birth defects through model organisms
Engin F, Lee B.
Elsevier. 2007; 129-148. Principals of Developmental Genetics. (Chapter 7).

Dominance of SOX9 function over RUNX2 during skeletogenesis
Zhou G, Zheng Q, Engin F, Munivez E, Chen Y, Sebald E, Krakow D, Lee B.
Proc. Natl. Acad. Sci. 2006; 103(50): 19004-9.