Type 1 diabetes mellitus (T1DM) affects approximately 3 million people in the United States and 10–20 million worldwide. The incidence of T1DM is on the rise globally around 3-5% per year, and rapidly increasing incidence in younger children is of the greatest concern. However, the underlying molecular mechanisms of T1D are not fully understood. Endoplasmic reticulum (ER) stress caused by protein misfolding as well as chronic inflammation, and environmental factors is emerging as a novel paradigm for diabetes pathogenesis. Our laboratory aims to identify these novel molecular mechanisms of T1DM pathogenesis with the aim of incorporating this knowledge into development of better therapeutic and preventive approaches for type 1 diabetes.
Requests for additional information on supporting Engin Lab research programs can be directed to:
Department of Biomolecular Chemistry
UW School of Medicine and Public Health
Room 1135G Biochemistry Building
420 Henry Mall
Madison, WI 53706
Phone: (608) 890-4631